Living in DeSoto County, Mississippi

By Kaspar Caldwell, REALTOR® · Reviewed

What it's like living in DeSoto County, Mississippi: local highlights near Hernando, getting around, home prices and $0 down eligibility.

Short answer

Mississippi's Memphis suburbs, with I-55, I-69 and I-269 for commuting. One of the fastest-growing counties in the state, with plenty of shopping and newer homes. Rural, USDA-eligible pockets sit just outside the larger cities. Much of the county is USDA-eligible for $0 down.

Key takeaways

  • Mississippi's Memphis suburbs, with I-55, I-69 and I-269 for commuting.
  • One of the fastest-growing counties in the state, with plenty of shopping and newer homes.
  • Rural, USDA-eligible pockets sit just outside the larger cities.
DeSoto County, Mississippi (county seat: Hernando).

Highlights

  • Mississippi's Memphis suburbs, with I-55, I-69 and I-269 for commuting.
  • One of the fastest-growing counties in the state, with plenty of shopping and newer homes.
  • Rural, USDA-eligible pockets sit just outside the larger cities.

Homes and prices

13 homes were for sale in USDA-eligible parts of DeSoto County under $325,000 as of October 8, 2026. Browse them on the county page or ask Kaspar Caldwell, REALTOR®, to send matches.

Frequently asked questions

What is the county seat of DeSoto County?

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Hernando

Is DeSoto County USDA-eligible?

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Much of it. Check each address on the USDA map.